• PPTOX VI conference

Welcome to the Faroe Islands, May 27-30, 2018

pPTOX VI conference

We warmly welcome you to Tórshavn, the capital of the Faroe Islands, in the heart of the North Atlantic. You will experience a unique culture and a breathtaking environment. Modern hotels and conference facilities will be at our disposal, and unique social events are being planned.

In regard to environmental hazards, fetal and early postnatal development seems to constitute the most vulnerable stage of human life. Among the effects of toxic exposures emphasized in the past were malformations and other adverse pregnancy outcomes. Subsequent studies highlighted maternal smoking and dietary deficiency or nutrient oversupply as important risk factors for child development and disease risks. In regard to industrial chemicals, dramatic effects of prenatal exposures have been recorded, with the Minamata Disease being the first major outbreak about 60 years ago. Recent research has revealed that more subtle effects during early development may also lead to functional deficits and increased disease risks later in life. This “fetal programming” hypothesis has gathered much support from both experimental and epidemiological studies. While health is determined by a variety of parameters, including genetic predisposition, health behaviors, and environmental factors, the interactions between them probably constitute a key to understanding the pathogenesis of important diseases and ill health. Substantial evidence now suggests that the prenatal and early postnatal environment is of crucial importance for gene expression, thereby affecting normal development and disease risks through adult life. The timing of exposure and the related gene-environment interactions are therefore crucial.

The overall purpose of the conference is to assess the weight of evidence and highlight new achievements on the effects of prenatal and early postnatal exposure to toxicants, as well their effects on the development. The overall aims of the conference are therefore:

  • to disseminate front-line information on developmental toxicity and fetal programming, in regard to environmental health research.
  • to enhance discussion and synthesis of information, thereby leading to discussions on improved research approaches to elucidate and unravel ambiguities in current understanding; and
  • to stimulate improved interaction between research strategies and needs for documentation that can inspire decision-making to protect against adverse effects from developmental exposures to environmental hazards or modifying.

Special attention will be on linking molecular, experimental and human studies, on combined of multiple stressors, on the use of prospective studies of birth cohorts and on the application of biomarkers in the monitoring of exposure to hazardous substances – in identifying individuals at increased risk diseases in the future.

Philippe Grandjean and Pál Weihe, Conference Co-Chairs

Publications from previous PPTOX conferences:

Grandjean P, Bellinger D, Bergman A, Cordier S, Davey-Smith G, Eskenazi B, Gee D, Gray K, Hanson M, van den Hazel P et al: The Faroes statement: human health effects of developmental exposure to chemicals in our environment. Basic Clin Pharmacol Toxicol 2008, 102(2):73-75. http://onlinelibrary.wiley.com/doi/10.1111/j.1742-7843.2007.00114.x/abstract

Darney S, Fowler B, Grandjean P, Heindel J, Mattison D, Slikker W, Jr.: Prenatal Programming and Toxicity II (PPTOX II): role of environmental stressors in the developmental origins of disease. Reprod Toxicol 2011, 31(3):271. http://www.sciencedirect.com/science/article/pii/S0890623810003217?via%3Dihub 

Barouki R, Gluckman PD, Grandjean P, Hanson M, Heindel JJ: Developmental origins of non-communicable disease: implications for research and public health. Environ Health 2012, 11(1):42. https://ehjournal.biomedcentral.com/articles/10.1186/1476-069X-11-42

Schug TT, Barouki R, Gluckman PD, Grandjean P, Hanson M, Heindel JJ: PPTOX III: environmental stressors in the developmental origins of disease--evidence and mechanisms. Toxicol Sci 2013, 131(2):343-350. https://academic.oup.com/toxsci/article/131/2/343/1641201

Grandjean P, Barouki R, Bellinger DC, Casteleyn L, Chadwick LH, Cordier S, Etzel RA, Gray KA, Ha EH, Junien C et al: Life-Long Implications of Developmental Exposure to Environmental Stressors: New Perspectives. Endocrinology 2015, 156(10):3408-3415. https://academic.oup.com/endo/article/2016/1/10/2351138

Heindel JJ, Balbus J, Birnbaum L, Brune-Drisse MN, Grandjean P, Gray K, Landrigan PJ, Sly PD, Suk W, Cory Slechta D et al: Developmental Origins of Health and Disease: Integrating Environmental Influences. Endocrinology 2015, 156(10):3416-3421. https://academic.oup.com/endo/article/2016/1/17/2351139

Barouki R, Melén E, Herceg Z, Beckers J, Chen J, Karagas M, Puga A, Xia Y, Chadwick L, Yan W, Audouze K, Slama R, Heindel J, Grandjean P, Kawamoto T, Nohara K. Epigenetics as a mechanism linking developmental exposures to long-term toxicity. Environ Int. 2018, 114: 77-86. https://doi.org/10.1016/j.envint.2018.02.014