• Programme

Conference Programme

DRAFT PPTOX VI program April 10, 2018 


Time (approx)

Sun, 27 May

Mon, 28 May

Tues, 29 May

Wed, 30 May

8:00- 9:00


Breakfast discussion



Plenary I                             

Plenary 3

Plenary 5






Symposia 1 & 2

Focused discussion 1

Symposia 5 & 6

Focused discussion 3

Symposia 9 & 10

Focused discussion 5


Lunch & posters

Lunch & posters






Symposia 3 & 4

Focused discussion 2

Symposia 7 & 8

Focused discussion 4

Plenary 6




Summary/ closing


Plenary 2

Plenary 4

Ferry trip

to Suderoy t/r

with dinner


Opening session


Posters /snacks



(Film screening)

(Cultural event)


Opening session at the University of the Faroes

Chair: Pal Weihe (Faroe Islands)

Siðrið Steenberg, Faroese Minister of Health

Annika Olsen, Mayor of the capital of Tórshavn

Sigurð í Jákupsstovu, Rector, University of Faroe Islands

Kim Brøsen, editor-in-chief, BCPT: The role of scientific journals in promoting health

Pal Weihe: The interface between the Faroese community and the birth cohorts

Philippe Grandjean: The Faroese birth cohort studies and their wider impacts


Plenary 1: Research priorities in children’s environmental health

Chairs: Ruth Etzel (USA) and Peter van den Hazel (Netherlands)

  1. Jordi Sunyer (Spain): Children as sentinels: Pre‐ and post‐natal brain development and urban air pollution
  2. Caitlin Howe (USA): Prenatal air pollution exposure and newborn thyroid function: Identifying vulnerable windows of exposure
  3. Samantha Drover (USA): Maternal thyroid hormone levels in mid gestation and IQ scores in preschool‐aged children: Effect measure modification by child sex
  4. Jacqueline Barkoski (USA): In utero pyrethroid pesticide exposure and neurodevelopmental outcomes from 6 ‐36 months of age in the MARBLES longitudinal cohort
  5. Cynthia Curl (USA): Effect of a randomized, blinded organic diet intervention on pesticide exposure among pregnant women



Plenary 2: Mechanistic evidence on developing origins of health and disease

Chairs: Latifa Najar (France) and Michael Ross (USA)

  1. Pascale Chavatte-Palmer (France): Validity of animal models of developmental toxicity
  2. Michael Ross (USA): Epigenetic DNA methylation-mediated programmed reduced neural stem cell proliferation and differentiation in SGA offspring
  3. Andrea Baccarelli (USA): Epigenetic abnormalities in children exposed to toxicants
  4. Latifa Najar (France): Role of dietary AGEs on oxidative stress and metabolic diseases
  5. Andrea Gore (USA): Endocrine disruptors and developmental programming of brain and behavior



Plenary 3: A decade of new insight since the first PPTox 

Chairs: Philippe Grandjean (Denmark) and Marie Vahter (Sweden)

  1. Jerry Heindel (USA): The developmental basis of disease: Environmental exposures and animal models II
  2. Morando Soffritti (Italy): The carcinogenic potential of non-ionizing radiation
  3. Niels Skakkebæk (Denmark): Clinical lessons from endocrine disruption effects on the male reproductive system
  4. Beate Ritz (USA): Two decades of research on air pollution and reproductive outcomes: What do we know and is there more to be done?



Plenary 4: Critical exposures and target organs for developmental toxicity

Chairs: Tony Fletcher (UK) and Leslie Stayner (USA)

  1. Karin Sørig Hougaard (Denmark): Multiorgan effects of nanoparticle exposures in pregnancy
  2. Charline Warembourg (Spain): Environmental exposures during early‐life and child blood pressure: an exposome approach
  3. Bruce Blumberg (USA): EDCs and the transgenerational inheritance of obesity
    18. Alicia Timme-Laragy (USA): The developing pancreas is a sensitive organ of toxicant exposures
  4. Ming-Tsang Wu (Taiwan): Interaction of melamine and di‐(2‐ethylhexyl) phthalate exposure on markers of early renal damage in children: The 2011 Taiwan food scandal



Plenary 5: Uncertainty and replication of BPA developmental toxicity

Chairs: Jerry Heindel (USA) and Gail Prins (USA)

  1. Luisa Camacho (USA): The CLARITY-BPA research program: Overview of study design
  2. Scott Belcher (USA): Effects of bisphenol A on incidence and severity of cardiac lesions in the NCTR-Sprague-Dawley rat: A CLARITY-BPA study
  3. Heather Patisaul (USA): CLARITY on brain and behavior: Reproducible evidence of low dose effects
  4. Gail Prins (USA): Chronic low-dose BPA effects on rat prostate stem cells and estrogen-driven carcinogenesis
  5. Fred vom Saal (USA): Replication – The devil is in the details



Plenary 6: Scientific priorities and public health implications

Chairs (TBC): Gerard Lasfargues (France) and Hiroshi Satoh (Japan)

  1. Marco Martuzzi (WHO): Research priorities in environment and health in Europe
  2. Ruth Etzel (USA): Environmental hazards as a threat to children’s health
  3. Matthew Gillman (USA): Visions for research collaboration
  4. Hans Bruyninckx (EEA): The Precautionary Principle in action


Philippe Grandjean (Denmark): Conference summary and visions


Parallel sessions



  1. Implications of placenta dysfunction

Chairs: Jane Cleal (UK) and Johanna Lepeule (France)

  1. Jane Cleal (UK): The placenta may mediate the effects of environmental exposures on fetal development
  2. Spyros Karakitsios (Greece): A generic PBPK model for assessing in utero toxicokinetics: application on bisphenol A and evaluation of placental β‐glucuronidase activity
  3. Claire Philippat (France): Effects of prenatal exposure to phthalates and phenols on fetal and placental weights
  4. Natasha E. Walker (UK): Changes in plasma membrane‐bound placental molecular transporters suggests mechanisms of fetal disease in response to maternal smoking
  5. Johanna Lepeule (France): Pregnancy exposure to tobacco smoking, atmospheric pollution and meteorological conditions and placental DNA methylation
  6. Aikaterini Zafeiri (UK): Maternal smoking is associated with changes in drug metabolising enzymes in the human fetus


  1. Benefits and risks from dietary intakes

Chairs: Latif Najar (France) and Michael Ross (USA)

  1. Chiara Talia (UK): In utero exposure to cigarette smoke is associated with sex and age specific changes in NAFLD pathway
  2. Helena Skröder (Sweden): Early‐life selenium status and cognitive function in childhood
  3. Marie Vahter (Sweden): Early‐life exposure to toxic and essential elements and child development: a longitudinal cohort in rural Bangladesh
  1. Joan Grimalt (Spain): Drivers of the accumulation of mercury and organochlorine pollutants in Mediterranean lean fish and dietary significance
  2. Maria S Petersen (Faroe Islands): Impact of dietary exposure to food contaminants on the risk of dementia


P1. Gemma Calamandrei (Italy): A multidisciplinary approach to study the critical role of early life nutrition in brain development: from birth cohorts to animal studies and backwards in the SELENIUS project

P2. Allison Kupsco (USA): Essential metals status during pregnancy is associated with decreased childhood cardio‐metabolic risk

P3. Tiril Borge (Norway): The importance of maternal diet quality during pregnancy on cognitive and behavioural outcomes in children: a systematic review and meta‐analysis

P4. Sung Ok Kwon (Korea): Polycyclic aromatic hydrocarbons‐born risk and nutrients‐born benefits in the diet of pregnant women in Korea

P5. Wojciech Hanke (Poland): Correlates of maternal diet during pregnancy

P6. Wojciech Hanke (Poland): Impact of micronutrients during pregnancy on children’s health and neurodevelopment


  1. Endocrine dysfunction

Chairs: Tina K. Jensen (Denmark) and Thad Schug (USA)

  1. Laura Vandenberg (USA): Pregnancy is a vulnerable period for the mother: effects of xenoestrogens on lactation and mammary gland health
  2. Amalie Timmermann (Denmark): PFAS exposure and shortened duration of breastfeeding
  3. Tony Fletcher (UK): Non-linearity in the dose response relationship of PFOA and sex hormones in early childhood
  4. Tina K. Jensen (Denmark): Maternal bisphenol A exposure associated with language development but not ADHD in toddlers among 538 mother-child pairs in the Odense Child Cohort
  5. Kristina Jakobsson (Sweden): High exposure to PFAS and thyroid hormones in children and teenagers
  6. Damaskini Valvi (USA): Developmental exposures to perfluoroalkyl substances and risk of type 2 diabetes in Faroese adults


P7. Jae-Hwan Lee (Republic of Korea): Effects of endocrine disrupting chemical on calcium signaling in differentiated cardiomyocyte from mouse embryonic stem cell

P8. Dinh Nam Tran (Republic of Korea): Bisphenol A and 4‐tert‐octylphenol disrupts embryo implantation in mice

P9. Richard Christian Jensen (Denmark): Perfluoroalkyl substances and glycemic status in pregnant Danish women: The Odense Child Cohort


  1. Developments in exposure assessment

Chairs: Marike Kolossa-Gehring (Germany) and Argelia Castaño (Spain):

  1. Marike Kolossa-Gehring (Germany): Key issues on the use of biological monitoring to identify developmental exposures and health risks - the HBM4EU approach.
  2. Clémentine Dereumeauz (France): Use of HBM data and biomarkers in the French Elfe cohort
  3. Ronit Machtinger (Israel): Exposure to phthalate metabolites and personal care products chemicals in Pregnant Women in Israel
  4. Ajda Trdin (Slovenia): Prenatal methylmercury exposure
  5. Mercè Garí (Germany): Temporal trends of organochlorine compounds and PBDEs from utero until 4 years of age in the Asturias INMA birth cohort (Spain)


P10. Ida Henriette Caspersen (Norway): Patterns of toxic and essential metal concentrations in blood measured in midpregnancy: The Norwegian Environmental Biomonitoring Program

P11. Anna Maria Ingelido (Italy): Perfluorinated compounds in women of reproductive age exposed to contaminated drinking water in the Veneto Region, Italy

P12. Maribel Casas (Spain): Variability of the non‐persistent chemical exposome in pregnant women and school-age children

P13. Gilles Riviere (France): Health risks related to the consumption of foodstuffs of animal origin contaminated by bisphenol A for pregnant women


  1. Systemic and immunotoxic effects

Chairs: Jamie Dewitt (USA) and Greet Schoeters (Belgium)

  1. Jérémy Botton (France): Linking experimental findings on obesogens to epidemiology
  2. Jamie Dewitt (USA): Impact of early-life environmental factors on the developing immune system
  3. Alaeddin Abukabda (USA): Group II innate lymphoid cells: a potential link between nanoparticle – associated acute pulmonary inflammation and uterine microvascular dysfunction
  4. Cyntia Beatriz Manzano Salgado (Spain): Prenatal exposure to perfluoroalkyl substances and immune and respiratory outcomes in children from a Spanish birth cohort study
  5. Stephanie Donauer (USA): Prenatal exposure to polychlorinated biphenyls and serum antibody concentration against measles, mumps, and rubella


P14. Barrett Welch (USA): Association between serum anti-diphtheria toxoid antibodies and drinking water arsenic exposure in a prospective birth cohort in rural Bangladesh.

P15. Margaret Karagas (USA): Prenatal mercury exposure in relation to immune outcomes in the New Hampshire Birth Cohort Study

P16. Youssef Oulhote (USA): Contrasting associations between exposure to environmental marine pollutants and reports of immune system disorders

P17. Marin Strøm (Faroe Islands): Maternal concentrations of persistent organochlorine pollutants and diagnoses of infections in the offspring during 25 years of follow up


  1. New and complex exposures

Chair: Karin Sørig Hougaard (Denmark) and Tom Webster (USA)

  1. Thomas Erren (Germany): Does perinatal light imprint circadian clocks and systems (PLICCS) and predispose to increased risks of cancer?
  2. Elizabeth Bowdridge (USA): ENM inhalation during gestation disrupts plasma estrogen and vascular kisspeptin reactivity
  3. Tim Nawrot (Belgium): Children’s urinary environmental carbon load
  4. Léa Maitre (Spain): Child molecular signatures of the prenatal and postnatal exposome in HELIX
  5. Youssef Oulhote (USA): Joint and individual neurotoxic effects of early life exposures to a chemical mixture: A multi‐pollutant approach combining ensemble learning and G‐computation


P18. Karin Sørig Hougaard (Denmark): Are maternal occupational exposure to combined lifting and psychosocial strain associated to growth in utero or gestational length?

P19. Hildegunn Dahl (Norway): A transgenerational study in mice: Chronic low grade pre-conceptional oxidative stress to grandfathers and susceptibility of grandsons

P20. Abigail Cartus (USA): Phthalate exposure and first trimester human chorionic gonadotropin (hCG) in women with low vs. high stress

P21. Hanne Frederiksen (Denmark): Time trends in urinary levels of bisphenol A and six analogues in young Danish men

P22. Youssef Oulhote (USA): Transplacental transfer efficiency and blood partitioning of perfluoralkyl substances


  1. Reproductive functions

Chairs: Melissa Perry (USA) and Maria S. Petersen (Faroe Islands)

  1. Barbara Hales (Canada): Maternal exposure to an environmentally relevant mixture of brominated flame retardants effects ovarian function in the dam and in her progeny
  2. Melissa Perry (USA): Sperm aneuploidy in a birth cohort of Faroese Men exposed to p,p’-DDE and PCB pollutants
  3. Gunnar Toft (Denmark): Influence of androgen receptor CAG repeat length on the effect of perfluorooctanoic acid on male reproductive function
  4. Charline Warembourg (France): Prenatal exposure to glycol ethers and variations in sex steroid hormones at birth
  5. Aleksandra Fucic (Croatia): Multidirectional matrix of endocrine disruptor mechanisms affecting perinatal development


P23. Amalie Timmermann (Denmark): PCB, DDE, methylmercury and secondary sex ratio

P24. Lars Rylander (Sweden): Perfluorooctanoic acid (PFOA) in early pregnancy and risk for preeclampsia

P25. Birgit Bjerre Høyer (Denmark): Impact of di‐2‐ethylhexyl phthalate metabolites on male reproductive function: A systematic review of human evidence

P26. Richard Pilsner (USA): Influence of phthalate and phthalate alternatives exposure on human sperm DNA methylation


  1. Molecular approaches

Chairs: Patricia Hunt (USA) and Tim Nawrot (Belgium) (TBC)

  1. Patricia Hunt (USA): Environmental effects on spermatogeneisis
  2. Lindsey Trevino (USA): Environmental exposures target epigenomic plasticity to reprogram Egr1 and one-carbon metabolism
  3. Whitney Cowell (USA): Associations between relative leukocyte telomere length in paired maternal‐newborn samples and financial strain, perceived stress and psychological distress
  4. Tim Nawrot (Belgium): p53 cord blood level and air pollution induced molecular ageing in early life
  5. Cheryl Rosenfeld (USA): Gene expression and DNA methylation changes in the hypothalamus and

hippocampus of adult rats developmentally exposed to Bisphenol A or Ethinyl Estradiol: A CLARITY‐BPA Consortium Study


P27. Jeong Jin Ahn (the Republic of Korea): Analysis of methylation and mRNA expression microarray for finding VOCs specific methylation biomarkers

P28. Karine Audouze (France): Linking environmental chemicals to health outcomes using a computational systems toxicology approach.

P29. Chisato Mori (Japan): Relationship between DNA methylation status in cord tissue and residue levels of PCBs in paired cord serum


  1. Arctic populations at risk

Chairs: Jon Øyvind Odland (Norway) and Pal Weihe (Faroe Islands)

  1. Pal Weihe (Faroe Islands): Health effects associated with measured levels of contaminants in the Arctic
  2. Maria S Petersen (Faroe Islands): Spermatogenic capacity in young Faroese men with elevated exposure to persistent pollutants
  3. Jon Øyvind Odland (Norway): Levels and effects of persistent toxic substances on pregnancy outcomes in the Eastern Arctic Hemisphere. The Norwegian‐Russian story.
  4. Eva Cecilie Bonefeld‐Jørgensen (Denmark): The Greenlandic birth cohort ACCEPT
  5. Peter Bjerregaard (Denmark): Social risk factors for child development in Greenland


P30. Flemming Nielsen (Denmark): Precursors of perfluoroalkyl substances (PFAS) as contributors to serum concentrations in young Faroese men

P31. Thorhallur Ingi Halldorsson (Iceland): Examining changes in persistent organochlorine pollutants following high consumption of farmed Atlantic Salmon: Results from an 8‐week dietary intervention study

P32. Christine Dalgård (Denmark): Gestational diabetes mellitus and umbilical cord serum 25-hydroxyvitamin D – a pooled analysis of two Faroese population-based birth cohorts


  1. Collaboration between birth cohorts

Chairs: Maribel Casas (Spain) and Reiko Kishi (Japan)

  1. Reiko Kishi (Japan): Birth cohorts in Asia: The importance, advantages and disadvantages of different-sized cohorts
  2. Maribel Casas (Spain): Lessons learned in cross‐cohort collaborations in Europe
  3. Thomas Webster (USA): Biomarkers of exposure during pregnancy: potential for bias amplification in studies of mixtures or multiple time‐windows
  4. Eva Govarts (Belgium): Prenatal exposure to endocrine disrupting chemicals and risk of being born small for gestational age: Pooled analysis of seven European birth cohorts
  5. Veerle Verheyen (Belgium): Residential exposure to fine particulate air pollution and maternal physiological stress in the second trimester of pregnancy


P33. Philip Lewis (Germany): Can disease start with perinatal light? Opportunities for “old” and “new” birth cohort studies to test a novel environmental hypothesis

P34. Parisa Montazeri (Spain): Social determinants of measured concentrations of environmental chemicals in pregnant women and their children

P35. Kelly Hunt (USA): ECHO Originating from the NICHD Fetal Growth Studies

P36. Léa Maitre (Spain): Cohort profile: The Human Early Life Exposome (HELIX) study ‐ A European

population‐based exposome cohort



Focused discussions


  1. Target organs

Chairs: Andrea Gore (USA) and Marco Martuzzi (WHO)

  1. Gary Hardiman (USA): Effects of environmental levels of EE2 on zebrafish embryo development: A systems level analysis
  2. Alicia Abellan (Spain): Prenatal exposure to organochlorine compounds and lung function until early adulthood
  3. Shohreh Farzan (USA): Impact of in utero lead and arsenic exposure on early childhood blood pressure
  4. Andrea Gore (USA): Sexually dimorphic effects of endocrine-disrupting chemicals on brain and behavior
  5. Troy Roepke (USA): Sex differences in metabolic disturbances due to maternal exposure to organophosphate flame retardants


P37. Denis Sarigiannis (Greece): The HERACLES Waste study: unraveling the associations between prenatal exposure to metals, post‐natal exposure to environmental and dietary factors and child cognitive capacity

P38. Kanae Karita (Japan): Interpretation of heart rate variability in light of methylmercury neurotoxicity: A review

P39. Maria S Petersen (Faroe Islands): Prenatal exposure to methylmercury and mortality

P40. Woo Jin Kim (the Republic of Korea): Regulatory effects of NADPH oxidase on cytotoxicity during alveolar epithelial cell differentiation

General discussion: Chairs and presenters


  1. Neurodevelopmental syndromes

Chairs: Sandra Ceccatelli (Sweden) and Dave Saint-Amour (Canada)

  1. Sandra Ceccatelli (Sweden): Novel endocrine disrupting potential of methylmercury uncovered using a sequential testing approach
  2. Dave Saint-Amour (Canada): Visual function in school‐age Guadeloupean children exposed to chlordecone
  3. Ondine von Ehrenstein (USA): Prenatal Pesticide Exposure and Autism in Children
  4. Claire Philippat (France): Prenatal exposure to organophosphate pesticides and risk of autism spectrum disorders and other non‐typical development at 3 years in a high‐risk cohort
  5. Stephanie Engel (USA): Gestational Exposure to Phthalates and Attention‐Deficit Hyperactivity Disorder in the Norwegian Mother and Child Cohort


P41. Anteneh Assefa Desalegn (Norway): Early‐life exposure to POPs in human breast milk and ASD in HUMIS‐NOMIC cohort

P42. Jónrit Halling (Faroe Islands): Autism Spectrum Disorder and vitamin D levels at birth: A case control study

P43. Helle Raun Andersen (Denmark): Dietary exposure to pyrethroids and chlorpyrifos during pregnancy and attention deficit hyperactivity disorder (ADHD) symptoms in preschool children

P44. Gro Dehli Villanger (Norway): Neonatal thyroid stimulating hormone and relationship with childhood ADHD

P45. Youssef Oulhote (USA): Gestational PFAS concentrations and thyroid hormone levels in Faroese pregnant women and newborns

P46. Thea Steen Skogheim (Norway): Prenatal exposure to perfluoroalkyl substances and associations with attention-deficit/hyperactivity disorder symptoms and cognitive functions in children 


  1. From research to intervention

Chairs: David Gee (UK) and John Peterson Myers (USA)

  1. David Gee (UK): The role of biases in explaining inconsistency in research results and evidence evaluations.
  2. Philippe Grandjean (Denmark): Late and delayed lessons on PFASs


P47. Mona Dai (USA): A comparative approach to assessing lifestage‐dependent susceptibility to estrogenic agent exposures and cancer development

P48. Katherine Fallace (USA): Approaches for considering fetal and early postnatal life stages in environmental health risk assessment

P49. Kam Sripada (Norway): Opportunities and challenges for children’s environmental health in the developing world

P50. Marya G. Zlatnik (USA): A story of health multimedia eBook improves environmental health literacy of thousands of health professionals

P51. Marya G. Zlatnik (USA): A recipe for prevention: Embedding environmental health in healthcare

General discussion: Chairs and presenters


  1. Pesticides and other neurotoxicants

Chair: Gemma Calamanderi (Italy) and Stephanie Engel (USA) (TBC)

  1. Edward Levin (USA): Developing zebrafish models to identify neurobehavioral toxic risks
  2. Matthew Rand (USA): Methylmercury toxicity targets embryonic muscle myogenesis
  3. Klara Gustin (Sweden): Cadmium exposure and cognitive abilities and behavior at 10 years of age: A

prospective cohort study

  1. Fróði Debes (Denmark): CHC‐modeling of neuropsychological test data ‐ The third Faroese Birth Cohort


P52. Mercè Garí (Germany): Human exposure to organophosphate and pyrethroid pesticides in occupational and general populations in Catalonia and Galicia (Spain)

P53. Nozomi Tatsuta (Japan): Intellectual ability of boys is affected by prenatal exposure to methylmercury in a birth cohort study in Japan

P54. Jordi Julvez (Spain): Prenatal methylmercury exposure and genetic interaction on child cognitive

function: An extended study

P55. Janja Snoj Tratnik (Slovenia): Low‐level mercury exposure, neurodevelopment and the role of genetic polymorphisms: evidence from Slovenian and Croatian birth cohorts

P56. Ida Henriette Caspersen (Norway): Seafood intake during pregnancy and child motor and communication skills at 1.5, 3 and 5 years: Results from MoBa

P57. Erin Butler (USA): Impact of in utero arsenic exposure on early childhood motor development

P58. Kristine Bjerve Gutzkow (Norway): Characterizing the cognitive and behavioural outcomes in HELIX sub‐cohort children

P59. Denis Sarigiannis (Greece): Adverse Outcome Pathway analysis of prenatal combined exposure to heavy metals and phthalates related to child neurodevelopment


  1. The gut microbiome

Chairs: Merete Eggesbø (Norway) and Derrick MacFabe (Canada):

  1. Merete Eggesbø (Norway): Maternal lifestyle factors and infant gut microbiome
  2. Derrick MacFabe (Canada): Enteric short chain fatty acids: microbial messengers of metabolism, mitochondria and mind: Implications in autism spectrum disorders
  3. Matthew Rand (USA): Gut microbiome characteristics associated with fish‐meal methylmercury metabolism and elimination
  4. Nina Iszatt (Norway): Environmental contaminants in breast milk are associated with gut bacteria composition and their metabolites in infants one-month old


P60. Sarah Blossom (USA): Irreversible effects of trichloroethylene on gut microbial community and gut

associated immune responses

General discussion: Chairs and presenters